Uncovering the Recipe for Cas9’s “Secret Sauce”
“What we’ve done here is uncover the secret sauce that makes typical Cas9 — the original Nobel molecule — so efficient and precise.”
IGI Researchers Use Robotic High-Throughput CRISPR Screens to Look for Mutations that Drive Cancers
IGI Investigators r use robotics to analyze nearly 2,000 previously unstudied mutations in a gene that could potentially cause cancer
Rewriting RNA: RSRT Funds Genetic Engineers in the AbuGoot Lab
Using RNA trans-splicing to fix Rett mutations
Wolf Prize Laureate Brian Staskawicz on 40 Years of Plant Immunity Research
Brian on waking up at 3 AM with ideas, how CRISPR is changing agriculture, and why he has "the best job in the world."
Announcing the Rising Stars Program: A New Collaboration Between the IGI and Historically Black Colleges and Universities
A pilot program will bring talented undergrads from HBCUs to IGI labs at UC Berkeley, UCSF, UC Davis, and UCLA for summer research.
From California to Kenya: The 2025 Cohort of the CRISPR Course for African Plant Scientists
Training scientists from across Africa in how to use CRISPR to edit crops.
A New Tool For Exploring Phage Genomes
Phage genomes represent an enormous pool of mysterious proteins that could potentially be harnessed to create genomic and biological tools.
3900 Trials and Counting: The Global Outlook on Genetic Medicines
The landscape of genomic medicine has changed rapidly over the past decade, and even more in the past five years.
IGI at 10 Years — 10 Key Achievements
On February 4, 2015, the IGI officially launched as the “Innovative Genomics Initiative,” a venture launched by CRISPR gene editing co-creator and not-yet Nobel Laureate Jennifer Doudna.
Using Tricks from Viruses to Get Inside Cells
The biggest challenge in genome editing is delivery — getting CRISPR components into the right cells and tissues (and making sure they don’t get where they’re not needed).
Teaming Up With CRISPR Pioneer Jennifer Doudna to Develop Genetic Medicines for Rett
Genome editing tools like CRISPR have the possibility to fix mutations that cause Rett syndrome.
A Review of Gene Therapy Clinical Trials for Rett by Taysha and Neurogene
A summary of data and what to watch for.
IGI is Awarded New Funding to Develop CRISPR Tools for Editing the Brain
A new project co-led by Jennifer Doudna has been awarded $1.25 million from the Rett Syndrome Research Trust to develop CRISPR tools to edit the brain.
CRISPRpedia: CRISPR & Ethics
CRISPRpedia is your source for clear, reliable CRISPR info.
First in Humans RNA Editing: "A Tremendously Big Deal"
RNA editing is one of a handful of promising new genomic techniques that has emerged over the past decade.
A Bacterial Immune System That Senses Genome Damage
IGI researchers describe a novel immune mechanism in the bacterial immune system Hachiman: sensing genome integrity.
Improving Editing Efficiency with Degradable LNPs
For genomic medicines, endocytosis is a double-edged sword.
Two IGI Women in Enterprising Science Fellows Receive $1 Million Each in Seed Funding
Derfogail Delcassian and Yue Clare Lou were each awarded non-dilutive seed funding that can to accelerate the commercialization of their discoveries.
Why We Need More Women in Bio-Entrepreneurship
IGI's 2023-2024 Women in Enterprising Science (WIES) Fellows share their thoughts on gender equity in bio-entrepreneurship.
Two New RSRT-Funded Projects That Use a Novel Approach to Deliver Genome Editors to the Brain
The projects use a novel delivery method combined with base editing and epigenome editing, respectively.
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